Another day, another injury update from the San Francisco 49ers.
Less than a full week into the 2025 NFL season and San Francisco is dealing with injuries to key players on offense. Tight end George Kittle is on injured reserve and wideout Jauan Jennings may miss time with injury as well from the 49ers’ Week 1 win over the Seattle Seahawks.
Head coach Kyle Shanahan confirmed on Friday, Sept. 12, that the team will be without quarterback Brock Purdy for Sunday’s road game against the New Orleans Saints, per multiple reports.
Purdy completed 26 of 35 passes for 277 yards, two touchdowns and two interceptions in the 49ers’ win last week in Seattle.
His second touchdown was the go-ahead score to tight end Jake Tonges.
With Purdy out, the 49ers will turn to former first-round pick Mac Jones to make his first start of the year. The one-time Pro Bowler signed with San Francisco this offseason to be the backup quarterback and brings multiple years of starting experience to the team.
When will Brock Purdy return?
Purdy’s return date is uncertain at this point. It depends on how fast he can recover from his turf toe and shoulder injuries.
Here’s the 49ers’ upcoming schedule through October:
Week 2: Sept. 14 at New Orleans Saints
Week 3: Sept. 21 vs. Arizona Cardinals
Week 4: Sept. 28 vs. Jacksonville Jaguars
Week 5: Oct. 2 at Los Angeles Rams on ‘Thursday Night Football’
Week 6: Oct. 12 at Tampa Bay Buccaneers
Week 7: Oct. 19 vs. Atlanta Falcons on ‘Sunday Night Football’
Week 8: Oct. 26 at Houston Texans
If Purdy’s recovery is two weeks, that puts him back in the lineup in Week 4 versus the Jaguars. If it’s more like five, Purdy may be starting again after the long break following Week 5’s ‘Thursday Night Football’ game in Los Angeles.
49ers QB depth chart
Jones is the next man up for San Francisco and the only other quarterback on the active roster following Week 1. Here’s how the position looks in San Francisco:
Brock Purdy (injured)
Mac Jones
Adrian Martinez (practice squad)
Kurtis Rourke (non-football injury list)
